TG-F2038-E02

3rd edition Mar 2024 K

1st edition Aug 2020 K

MEASUREMENT AND CONTROL OF BIOMEDICINE

MANUFACTURING PROCESSES

BIOSONIC

Single-use ultrasonic flowmeter for liquids

OUTLINE

BIOSONIC ultrasonic flowmeter is designed for measuring liquid

flow rates in biopharmaceutical manufacturing processes. It consists

of BS detector and SFC converter. The wetted parts of the detector

have biocompatibility (USP Class VI, FDA, BSE/TSE free) using

gamma-sterilizable material (PSU) for single-use.

Thanks to our unique ultrasonic flow measurement technology

developed over the years,

BIOSONIC can measure instantaneous

and integrated flow rates with high accuracy without affecting liquids

that contain cells. The construction is simple and smooth with no

moving parts in the detector that would cause stress to liquids, and

with no sealing mechanism that would cause liquid components to

accumulate and leave residues. The detector cable is detachable

and easy to install for single-use.

FEATURES

❑

Materials of wetted parts of the flow detector: Biocompatible (FDA,

USP Class VI, no TSE/BS animal derived components), gamma-

sterilizable (up to 50 kGy)

❑

Highly clean construction without causing stress to liquids or

leaving residues

❑

Wide rangeability

BS04SC

Range: 0 to 800 mL/min

BS04

Range: 0 to 3000 mL/min

BS06

Range: 0 to 8000 mL/min

BS10

Range: 0 to 20 L/min

BS15

Range: 0 to 50 L/min

BS20

Range: 0 to 80 L/min

❑

Liquids with kinematic viscosity of as high as 40 mm2/s can be

measured.

❑

Accuracy: Within

±1% of the reading at flow velocity of 1 m/s or

more

❑

Adjustment function to offset the effect on the measurement

values caused by a change in liquid temperature (optional)

❑

CE marking

❑

All the detectors are calibrated with the actual flow (water) at the

time of shipment.

❑

Soundness of the converter can be checked on site by using a

simulator (optional).

APPLICATIONS

❑

Noninvasive, highly accurate flow measurement of liquids in

biopharmaceutical manufacturing processes

❑

Flow control by combining pumps, control valves, etc.

❑

Installation into single-use kits and systems

OPERATING PRINCIPLE

The measuring fluid flows into the U-shaped tube, changes direction

by 90 degrees twice, and goes out as shown in Figure 1. Two

piezoelectric transducers A and B are mounted at both ends of

the measuring section. They emit and receive ultrasonic waves

alternately and measure the traveling times tA (A to B) and tB (B to

A) through the liquid. Without flow, tA is equal to tB. With flow, tA

becomes shorter and tB longer in proportion to the flow rate. Thus,

calculating tB - tA gives the flow rate of the liquid. tA and tB depend

on the size and shape of the tube and liquid viscosity. The actual flow

test data are stored in the linearizer in the converter, which enables

BIOSONIC to measure flow rates with high accuracy.

IN

OUT Piezoelectric

transducer B

Piezoelectric

transducer A

Travelling time tB

Travelling time tA

Figure 1 Operating principle